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Article

In vitro and in vivo modulations of benzo[c]phenanthrene-DNA adducts by DNA mismatch repair system.

Nucleic acids research - 15 Nov 2003

Wu Jianxin, Zhu Bei-Bei, Yu Jin, Zhu Hong, Qiu Lu, Kindy Mark S, Gu Liya, Seidel Albrecht, Li Guo-Min

Abstract excerpt

Benzo[c]phenanthrene dihydrodiol epoxide (B[c] PhDE) is well known as an important environmental chemical carcinogen that preferentially modifies DNA in adenine residues. However, the molecular mechanism by which B[c]PhDE induces tumorigenesis is not fully understood. In this report, we demonstrate that DNA mismatch repair (MMR), a genome maintenance system, plays an important role in B[c]PhDE-induced...

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Identifiers

PMID: 14602900
DOI: 10.1093/nar/gkg875
PMCID: PMC275569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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