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Article

Latitude and HLA-DRB1*04:05 independently influence disease severity in Japanese multiple sclerosis: a cross-sectional study.

Journal of neuroinflammation - 6 Sept 2016

Nakamura Yuri, Matsushita Takuya, Sato Shinya, Niino Masaaki, Fukazawa Toshiyuki, Yoshimura Satoshi, Hisahara Shin, Isobe Noriko, Shimohama Shun, Watanabe Mitsuru, Yoshida Kazuto, Houzen Hideki, Miyazaki Yusei, Yamasaki Ryo, Kikuchi Seiji, Kira Jun-Ichi

Abstract excerpt

BACKGROUND: Higher latitude and human leukocyte antigen (HLA)-DRB1*04:05 increase susceptibility to multiple sclerosis (MS) in the Japanese population, but their effects on disease severity are unknown. We aimed to clarify the effects of latitude and the HLA-DRB1 and HLA-DPB1 genes on disease severity in Japanese patients with MS. METHODS: We enrolled 247 MS patients and 159 healthy controls (HCs) from the...

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Identifiers

PMID: 27599848
DOI: 10.1186/s12974-016-0695-3
PMCID: PMC5013608

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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