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Article

Loss of heterozygosity on 8p in prostate cancer implicates a role for dematin in tumor progression.

Cancer genetics and cytogenetics - 1 Nov 1999

Lutchman M, Pack S, Kim A C, Azim A, Emmert-Buck M, van Huffel C, Zhuang Z, Chishti A H

Abstract excerpt

Dematin is a cytoskeletal protein that bundles actin filaments in a phosphorylation-dependent manner. The primary structure of dematin is organized into an N-terminal core domain of unknown function and a C-terminal domain that is homologous to the "headpiece" domain of villin. We have previously localized the dematin gene on human chromosome 8p21.1, a region distal to the ankyrin locus for hereditary...

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PMID: 10565303
DOI: 10.1016/s0165-4608(99)00081-3

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