Article
Inhibition of ADAM9 expression induces epithelial phenotypic alterations and sensitizes human prostate cancer cells to radiation and chemotherapy.
The Prostate - 15 Feb 2011
Josson Sajni, Anderson Cynthia S, Sung Shian-Ying, Johnstone Peter A S, Kubo Hiroyuki, Hsieh Chia-Ling, Arnold Rebecca, Gururajan Murali, Yates Clayton, Chung Leland W K
Abstract excerpt
INTRODUCTION: Recent studies demonstrated the importance of ADAM9 in prostate cancer relapse upon therapy. In this study, we determined the role of ADAM9 in the therapeutic resistance to radiation and chemotherapy. MATERIALS AND METHODS: ADAM9 was either transiently or stably knocked down in C4-2 prostate cancer cells. The sensitivity of ADAM9 knockdown cells toward radiation and chemotherapeutic agents were...
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