Commonly occurring loss and mutation of the MXI1 gene in prostate cancer.

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Article

Commonly occurring loss and mutation of the MXI1 gene in prostate cancer.

Genes, chromosomes & cancer - 1 Aug 1998

Prochownik E V, Eagle Grove L, Deubler D, Zhu X L, Stephenson R A, Rohr L R, Yin X, Brothman A R

Abstract excerpt

One of the most common chromosomal abnormalities in prostate cancer involves loss of 10q22-qter. Rarely, a smaller deletion, involving 10q24-q25, has been observed, suggesting the presence of a tumor suppressor gene at this site. We previously demonstrated that the MXI1 gene maps to 10q24-q25 and...

Topics

Basic Helix-Loop-Helix Transcription Factors
Chromosome Deletion
DNA, Neoplasm
DNA-Binding Proteins
Gene Deletion
Helix-Loop-Helix Motifs
Humans
In Situ Hybridization, Fluorescence
Male
Mutation
Neoplasm Recurrence, Local
Prostatic Neoplasms
Transcription Factors
Tumor Suppressor Proteins

Source

Open in PubMed

Identifiers

PMID: 9669667

Genes

MXI1
MAX
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9669667-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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