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Article

Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia.

Cancer research - 15 Jul 1995

Emmert-Buck M R, Vocke C D, Pozzatti R O, Duray P H, Jennings S B, Florence C D, Zhuang Z, Bostwick D G, Liotta L A, Linehan W M

Abstract excerpt

The development and progression of human prostate cancer is associated with genetic abnormalities in tumor cells. Inactivation of tumor suppressor genes due to allelic loss is thought to be an important mechanism of gene alteration in prostatic neoplasms. In this study we examined allelic loss on chromosome 8p12-21 in microdissected samples of normal prostatic epithelium, high grade prostatic intraepithelial...

Topics

Alleles
Carcinoma in Situ
Chromosomes, Human, Pair 8
Disease Progression
Dissection
Gene Deletion
Heterozygote
Humans
Male
Precancerous Conditions
Prostatic Neoplasms

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PMID: 7606709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7606709-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia.PMID 7606709Read ↗

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