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Article

Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia.

Cancer research - 15 Jul 1995

Emmert-Buck M R, Vocke C D, Pozzatti R O, Duray P H, Jennings S B, Florence C D, Zhuang Z, Bostwick D G, Liotta L A, Linehan W M

Abstract excerpt

The development and progression of human prostate cancer is associated with genetic abnormalities in tumor cells. Inactivation of tumor suppressor genes due to allelic loss is thought to be an important mechanism of gene alteration in prostatic neoplasms. In this study we examined allelic loss on chromosome 8p12-21 in microdissected samples of normal prostatic epithelium, high grade prostatic intraepithelial...

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PMID: 7606709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia.PMID 7606709Read ↗

Analysis of 99 microdissected prostate carcinomas reveals a high frequency of allelic loss on chromosome 8p12-21.Semantic proximity Read ↗

Independent origin of multiple foci of prostatic intraepithelial neoplasia: comparison with matched foci of prostate carcinoma.Semantic proximity Read ↗

Allelotyping analysis at chromosome arm 8p of high-grade prostatic intraepithelial neoplasia and incidental, latent, and clinical prostate cancers.Semantic proximity Read ↗

Determination of a minimal deletion interval on chromosome band 8p21 in sporadic prostate cancer†Semantic proximity Read ↗

Homozygous and frequent deletion of proximal 8p sequences in human prostate cancers: Identification of a potential tumor suppressor gene siteSemantic proximity Read ↗

Review of allelic loss and gain in prostate cancer.Semantic proximity Read ↗

Loss of chromosome arm 8p loci in prostate cancer: mapping by quantitative allelic imbalance.Semantic proximity Read ↗

Allelotyping analysis at chromosome 13q of high-grade prostatic intraepithelial neoplasia and clinically insignificant and significant prostate cancers.Semantic proximity Read ↗

Homozygous deletions at 8p22 and 8p21 in prostate cancer implicate these regions as the sites for candidate tumor suppressor genes.Semantic proximity Read ↗

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Loss of Heterozygosity Analysis and DNA Copy Number Measurement on 8p in Bladder Cancer Reveals Two Mechanisms of Allelic LossSemantic proximity Read ↗

Tumour-suppressor genes in prostatic oncogenesis: a positional approach.Semantic proximity Read ↗

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