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Article

Headpiece domain of dematin regulates calcium mobilization and signaling in platelets.

The Journal of biological chemistry - 30 Nov 2012

Wieschhaus Adam J, Le Breton Guy C, Chishti Athar H

Abstract excerpt

Dematin is a broadly expressed membrane cytoskeletal protein that has been well characterized in erythrocytes and to a lesser extent in non-erythroid cells. However, dematin's function in platelets is not known. Here, we show that dematin is abundantly expressed in both human and mouse platelets. Platelets harvested from the dematin headpiece knock-out (HPKO) mouse model exhibit a striking defect in the...

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Identifiers

PMID: 23060452
DOI: 10.1074/jbc.M112.364679
PMCID: PMC3510821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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