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Article

Headpiece domain of dematin regulates calcium mobilization and signaling in platelets.

The Journal of biological chemistry - 30 Nov 2012

Wieschhaus Adam J, Le Breton Guy C, Chishti Athar H

Abstract excerpt

Dematin is a broadly expressed membrane cytoskeletal protein that has been well characterized in erythrocytes and to a lesser extent in non-erythroid cells. However, dematin's function in platelets is not known. Here, we show that dematin is abundantly expressed in both human and mouse platelets. Platelets harvested from the dematin headpiece knock-out (HPKO) mouse model exhibit a striking defect in the...

Topics

Animals
Blood Platelets
Calcium
Calcium Signaling
Cardiovascular Diseases
Cytoskeletal Proteins
Cytosol
Erythrocyte Membrane
Hemostasis
Humans
Mice
Microfilament Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Biological

Mutation

Platelet Activation

Protein Structure, Tertiary

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 23060452
DOI: 10.1074/jbc.M112.364679
PMCID: PMC3510821

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23060452-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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