Article
Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations.
Cancer research - 1 Nov 1996
Simoneau A R, Spruck C H, Gonzalez-Zulueta M, Gonzalgo M L, Chan M F, Tsai Y C, Dean M, Steven K, Horn T, Jones P A
Abstract excerpt
The most common genetic alteration identified to date in bladder cancer is loss of heterozygosity (LOH) of chromosome 9, suggesting the presence of possible tumor suppressor genes on this chromosome. We attempted to map the location of these genes by analyzing 69 primary transitional cell carcino...
Topics
- Carcinoma, Transitional Cell
- Cell Cycle Proteins
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 9
- Drosophila Proteins
- GPI-Linked Proteins
- Genes, Tumor Suppressor
- Humans
- Insect Hormones
- Membrane Proteins
- Mutation
- Receptors, Cell Surface