Article
Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations.
Cancer research - 1 Nov 1996
Simoneau A R, Spruck C H, Gonzalez-Zulueta M, Gonzalgo M L, Chan M F, Tsai Y C, Dean M, Steven K, Horn T, Jones P A
Abstract excerpt
The most common genetic alteration identified to date in bladder cancer is loss of heterozygosity (LOH) of chromosome 9, suggesting the presence of possible tumor suppressor genes on this chromosome. We attempted to map the location of these genes by analyzing 69 primary transitional cell carcinomas of the bladder with a panel of microsatellite markers for LOH on chromosome 9. Monosomy 9 (defined by LOH of all...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.