Article
p53 mutations in lung cancers from Japanese mustard gas workers.
Carcinogenesis - 1 Oct 1994
Takeshima Y, Inai K, Bennett W P, Metcalf R A, Welsh J A, Yonehara S, Hayashi Y, Fujihara M, Yamakido M, Akiyama M
Abstract excerpt
Mustard gas (MG) is a mutagenic and carcinogenic alkylating agent, and is a known risk factor for occupational lung cancer. Our hypothesis is that lung cancers from MG workers contain mutations (G:C to A:T transitions) as the result of MG-produced DNA promutagenic adducts in the p53 tumor suppres...
Topics
- Aged
- Aged, 80 and over
- Case-Control Studies
- Codon
- DNA Damage
- DNA, Neoplasm
- Exons
- Genes, p53
- Humans
- Japan
- Lung Neoplasms
- Male
- Middle Aged
- Mustard Gas
- Mutation
- Occupational Diseases
- Point Mutation