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Article

p53 mutations in lung cancers from Japanese mustard gas workers.

Carcinogenesis - 1 Oct 1994

Takeshima Y, Inai K, Bennett W P, Metcalf R A, Welsh J A, Yonehara S, Hayashi Y, Fujihara M, Yamakido M, Akiyama M

Abstract excerpt

Mustard gas (MG) is a mutagenic and carcinogenic alkylating agent, and is a known risk factor for occupational lung cancer. Our hypothesis is that lung cancers from MG workers contain mutations (G:C to A:T transitions) as the result of MG-produced DNA promutagenic adducts in the p53 tumor suppressor gene. We analyzed 12 primary lung cancers from Japanese MG factory workers and 12 lung cancers from non-exposed...

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PMID: 7955036
DOI: 10.1093/carcin/15.10.2075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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