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Article

p53 mutations in lung cancers from non-smoking atomic-bomb survivors.

Lancet (London, England) - 1 Jan 2000

Takeshima Y, Seyama T, Bennett W P, Akiyama M, Tokuoka S, Inai K, Mabuchi K, Land C E, Harris C C

Abstract excerpt

Tobacco smoke contains many carcinogens and has been linked with the development of lung cancer. We sequenced the conserved regions of the p53 tumour suppressor gene in lung cancers from 17 non-smokers from Hiroshima, Japan; 9 were atomic-bomb survivors. The mutations were predominantly transitions (all G:C to A:T); there were no G:C to T:A transversions. By contrast, lung cancers from 77 Japanese smokers have a...

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Identifiers

PMID: 7902903
DOI: 10.1016/s0140-6736(05)80087-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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