p53 mutations in lung cancers from non-smoking atomic-bomb survivors.

doi:10.1016/s0140-6736(05)80087-x

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Article

p53 mutations in lung cancers from non-smoking atomic-bomb survivors.

Lancet (London, England) - 1 Jan 2000

Takeshima Y, Seyama T, Bennett W P, Akiyama M, Tokuoka S, Inai K, Mabuchi K, Land C E, Harris C C

Abstract excerpt

Tobacco smoke contains many carcinogens and has been linked with the development of lung cancer. We sequenced the conserved regions of the p53 tumour suppressor gene in lung cancers from 17 non-smokers from Hiroshima, Japan; 9 were atomic-bomb survivors. The mutations were predominantly transitio...

Topics

Adult
Aged
DNA Mutational Analysis
Genes, p53
Humans
Japan
Lung Neoplasms
Middle Aged
Mutation
Neoplasms, Radiation-Induced
Nuclear Warfare
Retrospective Studies
Smoking

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