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Article

p16INK4a Modulates p53 in Primary Human Mammary Epithelial Cells

1 Nov 2006

Abstract excerpt

p16(INK4a) (p16) and p53 are tumor suppressor genes that are inactivated during carcinogenesis in many tumors. Here we show that p16 gene activity inversely modulates p53 status and function in primary human mammary epithelial cells. Reduced levels of p16 protein stabilize p53 protein through inhibition of proteolytic degradation, and this increase in p53 protein levels enhances the cellular response to...

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Identifiers

PMID: 17079452
DOI: 10.1158/0008-5472.can-06-1594

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Source receipt: pubmed, retrieved 7 Sept 2026.

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