Article
spen encodes an RNP motif protein that interacts with Hox pathways to repress the development of head-like sclerites in the Drosophila trunk.
Development (Cambridge, England) - 1 Dec 1999
Wiellette E L, Harding K W, Mace K A, Ronshaugen M R, Wang F Y, McGinnis W
Abstract excerpt
Drosophila has eight Hox proteins, and they require factors acting in parallel to regulate different segmental morphologies. Here we find that the Drosophila gene split ends (spen), has a homeotic mutant phenotype, and appears to encode such a parallel factor. Our results indicate that spen plays two important segment identity roles. One is to promote sclerite development in the head region, in parallel with Hox...
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