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Article

Requirement of Split ends for epigenetic regulation of Notch signal-dependent genes during infection-induced hemocyte differentiation.

Molecular and cellular biology - 1 Mar 2009

Jin Li Hua, Choi Jung Kyoon, Kim Byungil, Cho Hwan Sung, Kim Jihyun, Kim-Ha Jeongsil, Kim Young-Joon

Abstract excerpt

Drosophila producing a mutant form of the putative transcription coregulator, Split ends (Spen), originally identified in the analysis of neuronal development, display diverse immune defects. In order to understand the role of Spen in the innate immune response, we analyzed the transcriptional defects associated with spen mutant hemocytes and their relationship to the Notch signaling pathways. Spen is regulated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19139277
DOI: 10.1128/MCB.01239-08
PMCID: PMC2648238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Requirement of Split ends for epigenetic regulation of Notch signal-dependent genes during infection-induced hemocyte differentiation.PMID 19139277Read ↗

split ends encodes large nuclear proteins that regulate neuronal cell fate and axon extension in the Drosophila embryo.Semantic proximity Read ↗

The product of the split ends gene is required for the maintenance of positional information during Drosophila development.Semantic proximity Read ↗

The nucleosome remodeling factor (NURF) regulates genes involved in Drosophila innate immunity.Semantic proximity Read ↗

Neurogenic phenotypes induced by RNA interference with bHLH genes of the Enhancer of split complex of Drosophila melanogaster.Semantic proximity Read ↗

Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling.Semantic proximity Read ↗

spen encodes an RNP motif protein that interacts with Hox pathways to repress the development of head-like sclerites in the Drosophila trunk.Semantic proximity Read ↗

Persistent expression of genes of the enhancer of split complex suppresses neural development in Drosophila.Semantic proximity Read ↗

split ends, a new component of the Drosophila EGF receptor pathway, regulates development of midline glial cells.Semantic proximity Read ↗

Echinoid mutants exhibit neurogenic phenotypes and show synergistic interactions with the Notch signaling pathway.Semantic proximity Read ↗

A chimeric enhancer-of-split transcriptional activator drives neural development and achaete-scute expression.Semantic proximity Read ↗

The SUMO-targeted ubiquitin ligase, Dgrn, is essential for Drosophila innate immunity.Semantic proximity Read ↗

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