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Article

The product of the split ends gene is required for the maintenance of positional information during Drosophila development.

BMC developmental biology - 13 Dec 2004

Mace Kimberly, Tugores Antonio

Abstract excerpt

BACKGROUND: The Drosophila split ends (spen) gene encodes a large nuclear protein containing three RNP-type RNA binding motifs, and a conserved transcriptional co-repressor-interacting domain at the C-terminus. Genetic analyses indicate that spen interacts with pathways that regulate the function of Hox proteins, the response to various signaling cascades and cell cycle control. Although spen mutants affect only...

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Identifiers

PMID: 15596016
DOI: 10.1186/1471-213X-4-15
PMCID: PMC544560

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