Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequent loss of imprinting of PEG1/MEST in invasive breast cancer.

Cancer research - 1 Nov 1999

Pedersen I S, Dervan P A, Broderick D, Harrison M, Miller N, Delany E, O'Shea D, Costello P, McGoldrick A, Keating G, Tobin B, Gorey T, McCann A

Abstract excerpt

The human PEG1 gene is a newly identified imprinted gene on 7q32. Genetic aberrations of this chromosomal region are often detected in invasive breast carcinomas. In this study, we show monoallelic PEG1 expression in normal breast tissue, indicating the presence of a functional imprint, and more importantly, we demonstrate loss of imprinting (LOI) in all of seven informative invasive breast carcinomas. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 7
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genomic Imprinting

Share to Loss of Heterozygosity

Share to Models, Statistical

Share to Neoplasm Invasiveness

Share to Proteins

Source

Identifiers

PMID: 10554015

Genes

MEST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent loss of imprinting of PEG1/MEST in invasive breast cancer.PMID 10554015Read ↗

Promoter switch: a novel mechanism causing biallelic PEG1/MEST expression in invasive breast cancer.Semantic proximity Read ↗

Imprinting of PEG1/MEST isoform 2 in human placenta.Semantic proximity Read ↗

Monoallelic expression of human PEG1/MEST is paralleled by parent-specific methylation in fetuses.Semantic proximity Read ↗

Isoform-Specific Imprinting of the Human PEG1/MEST GeneSemantic proximity Read ↗

Frequent loss of imprinting of IGF2 and MEST in lung adenocarcinomaSemantic proximity Read ↗

An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa.Semantic proximity Read ↗

Genomic Structure and Parent-of-Origin-Specific Methylation of Peg1Semantic proximity Read ↗

Imprinted tumor suppressor genes <i>ARHI</i> and <i>PEG3</i> are the most frequently down‐regulated in human ovarian cancers by loss of heterozygosity and promoter methylationSemantic proximity Read ↗

Loss of imprinting of IGF2 in fibroadenomas and phyllodes tumors of the breast.Semantic proximity Read ↗

Loss of imprinting of the insulin-like growth factor II (IGF2) gene in esophageal normal and adenocarcinoma tissues.Semantic proximity Read ↗

Peg1/Mest imprinted gene on chromosome 6 identified by cDNA subtraction hybridizationSemantic proximity Read ↗

<i>PEG10</i> Is a c-MYC Target Gene in Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.