Imprinted tumor suppressor genes <i>ARHI</i> and <i>PEG3</i> are the most frequently down‐regulated in human ovarian cancers by loss of heterozygosity and promoter methylation

Abstract excerpt

BACKGROUND: Imprinted tumor suppressor genes may be particularly important in the pathogenesis of ovarian cancer. Two imprinted genes, paternally expressed 3 (PEG3) and aplasia Ras homologue member I (ARHI), are the most frequently down-regulated in ovarian cancers on gene expression arrays. METHODS: PEG3 and ARHI expression levels were evaluated with real-time reverse-transcriptase polymerase chain reaction...

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