Article
Imprinting of PEG1/MEST isoform 2 in human placenta.
Placenta - 1 Jan 2000
McMinn J, Wei M, Sadovsky Y, Thaker H M, Tycko B
Abstract excerpt
The PEG1 gene (a.k.a. MEST) is expressed in human placental trophoblast and endothelium, and data from knockout mice show that this gene regulates placental and fetal growth. Isoform 1 of PEG1 mRNA initiates from exon 1c and produces the long form of the MEST protein. This isoform is imprinted, with expression only from the paternal allele in many human and mouse organs, including placenta. In contrast, PEG1...
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