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Article

Loss of imprinting of IGF2 in fibroadenomas and phyllodes tumors of the breast.

Oncology reports - 1 Mar 2016

Mishima Chieko, Kagara Naofumi, Tanei Tomonori, Naoi Yasuto, Shimoda Masafumi, Shimomura Atsushi, Shimazu Kenzo, Kim Seung Jin, Noguchi Shinzaburo

Abstract excerpt

Loss of imprinting (LOI) of insulin-like growth factor 2 (IGF2) is thought to be implicated in the pathogenesis of some tumors by upregulating IGF2 mRNA but its role in the pathogenesis of fibroadenomas (FAs) and phyllodes tumors (PTs) of the breast is yet to be studied. LOI of IGF2 was investigated in 25 FAs and 17 PTs which were heterozygous for Apa I polymorphism, and was found to be present in 13 FAs and 12...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26676988
DOI: 10.3892/or.2015.4489

Genes

IGF2
MED12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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