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Article

<i>PEG10</i> Is a c-MYC Target Gene in Cancer Cells

15 Jan 2006

Abstract excerpt

The product of the imprinted gene paternally expressed gene-10 (PEG10) has been reported to support proliferation in hepatocellular carcinomas, but how this gene is regulated has been an open question. We find that MYC knockdown by RNA interference suppresses PEG10 expression in Panc1 pancreatic carcinoma and HepG2 hepatocellular carcinoma cells and that knockdown of PEG10 inhibits the proliferation of Panc1,...

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Share to Epigenetics and DNA Methylation
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PMID: 16423995
DOI: 10.1158/0008-5472.can-05-1553

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<i>PEG10</i> Is a c-MYC Target Gene in Cancer CellsPMID 16423995Read ↗

PEG10 overexpression induced by E2F-1 promotes cell proliferation, migration, and invasion in pancreatic cancerSemantic proximity Read ↗

PEG10 as an oncogene: expression regulatory mechanisms and role in tumor progressionSemantic proximity Read ↗

Paternally Expressed Gene 10 (PEG10) Promotes Growth, Invasion, and Survival of Bladder CancerSemantic proximity Read ↗

An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa.Semantic proximity Read ↗

The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate CancerSemantic proximity Read ↗

<i>peg10</i>, an imprinted gene, plays a crucial role in adipocyte differentiationSemantic proximity Read ↗

PEG10 plays a crucial role in human lung cancer proliferation, progression, prognosis and metastasisSemantic proximity Read ↗

Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethalitySemantic proximity Read ↗

Mouse <i>Peg9/Dlk1</i> and human <i>PEG9/DLK1</i> are paternally expressed imprinted genes closely located to the maternally expressed imprinted genes: mouse <i>Meg3/Gtl2</i> and human <i>MEG3</i>Semantic proximity Read ↗

Transcriptional regulator CTR9 promotes hepatocellular carcinoma progression and metastasis via increasing PEG10 transcriptional activitySemantic proximity Read ↗

Overexpression of the paternally expressed gene 10 (PEG10) from the imprinted locus on chromosome 7q21 in high-risk B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

A Retrotransposon-Derived Gene, PEG10, Is a Novel Imprinted Gene Located on Human Chromosome 7q21Semantic proximity Read ↗

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