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Article

Genomic Structure and Parent-of-Origin-Specific Methylation of Peg1

1 Oct 1997

Abstract excerpt

We previously identified Peg1/Mest as a novel paternally expressed gene in the developing mouse embryo. The human PEG1 gene was recently assigned to 7q32 and shown to be imprinted and paternally expressed. Therefore, PEG1 deficiency could participate in the aetiology of pre- and post-natal growth retardation associated with maternal uniparental disomy 7 in humans. We have now initiated the characterization of the...

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Epigenetics and DNA Methylation
Genetic Syndromes and Imprinting
Prenatal Screening and Diagnostics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9302270
DOI: 10.1093/hmg/6.11.1907

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Genomic Structure and Parent-of-Origin-Specific Methylation of Peg1PMID 9302270Read ↗

Monoallelic expression of human PEG1/MEST is paralleled by parent-specific methylation in fetuses.Semantic proximity Read ↗

An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa.Semantic proximity Read ↗

Imprinting of PEG1/MEST isoform 2 in human placenta.Semantic proximity Read ↗

Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing.Semantic proximity Read ↗

Isoform-Specific Imprinting of the Human PEG1/MEST GeneSemantic proximity Read ↗

Genetic-epigenetic intersection in trophoblast differentiation: Implications for extraembryonic tissue functionSemantic proximity Read ↗

Mouse <i>Peg9/Dlk1</i> and human <i>PEG9/DLK1</i> are paternally expressed imprinted genes closely located to the maternally expressed imprinted genes: mouse <i>Meg3/Gtl2</i> and human <i>MEG3</i>Semantic proximity Read ↗

Deletion of the paternal allele of the imprinted MEST/PEG1 region in a patient with Silver-Russell syndrome features.Semantic proximity Read ↗

Peg1/Mest imprinted gene on chromosome 6 identified by cDNA subtraction hybridizationSemantic proximity Read ↗

Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32Semantic proximity Read ↗

The PcG gene Sfmbt2 is paternally expressed in extraembryonic tissues.Semantic proximity Read ↗

Arginine N-methyltransferase 1 is required for early postimplantation mouse development, but cells deficient in the enzyme are viable.Semantic proximity Read ↗

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