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Article

Promoter switch: a novel mechanism causing biallelic PEG1/MEST expression in invasive breast cancer.

Human molecular genetics - 1 Jun 2002

Pedersen Inge Søkilde, Dervan Peter, McGoldrick Alo, Harrison Michèle, Ponchel Frederique, Speirs Valerie, Isaacs John D, Gorey Thomas, McCann Amanda

Abstract excerpt

We have previously reported on the biallelic expression of the imprinted PEG1/MEST gene in infiltrating carcinomas of the breast. Putative loss of imprinting (LOI) of PEG1/MEST has subsequently also been implicated in the aetiology of lung adenocarcinomas and colon cancer. Taking advantage of our previous study, identifying seven infiltrating carcinomas of the breast, displaying biallelic PEG1/MEST expression, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 12023987
DOI: 10.1093/hmg/11.12.1449

Genes

MEST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Promoter switch: a novel mechanism causing biallelic PEG1/MEST expression in invasive breast cancer.PMID 12023987Read ↗

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Imprinting of PEG1/MEST isoform 2 in human placenta.Semantic proximity Read ↗

An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa.Semantic proximity Read ↗

Isoform-Specific Imprinting of the Human PEG1/MEST GeneSemantic proximity Read ↗

Use of real-time RT-PCR for the detection of allelic expression of an imprinted gene.Semantic proximity Read ↗

Monoallelic expression of human PEG1/MEST is paralleled by parent-specific methylation in fetuses.Semantic proximity Read ↗

Tissue-specific imprinting of the ZAC/PLAGL1 tumour suppressor gene results from variable utilization of monoallelic and biallelic promoters.Semantic proximity Read ↗

Peg1/Mest imprinted gene on chromosome 6 identified by cDNA subtraction hybridizationSemantic proximity Read ↗

Frequent loss of imprinting of IGF2 and MEST in lung adenocarcinomaSemantic proximity Read ↗

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Bidirectional imprinting of a single gene: GNAS1 encodes maternally, paternally, and biallelically derived proteins.Semantic proximity Read ↗

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