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Article

Frequent loss of imprinting of IGF2 and MEST in lung adenocarcinoma

1 Aug 2001

Abstract excerpt

Genomic imprinting is a parental origin-specific chromosomal modification that causes differential expression of maternal and paternal alleles of a gene. Accumulating evidence suggests that deregulation of imprinted genes, including loss of imprinting (LOI), plays a role in oncogenesis. In the present study, we investigated allelic expression of six imprinted genes in human lung adenocarcinomas as well as in...

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Share to Epigenetics and DNA Methylation
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Share to Prenatal Screening and Diagnostics

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PMID: 11536368
DOI: 10.1002/mc.1053

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