Article
Abberant chemotaxis and differentiation in Dictyostelium mutant fgdC with a defective regulation of receptor-stimulated phosphoinositidase C.
Journal of cell science - 1 Dec 1991
Bominaar A A, Kesbeke F, Snaar-Jagalska B E, Peters D J, Schaap P, Van Haastert P J
Abstract excerpt
Dictyostelium cells use extracellular cyclic AMP both as a chemoattractant and as a morphogen inducing cell-type-specific gene expression. Cyclic AMP binds to surface receptors, activates one or more G-proteins, and stimulates adenylate cyclase, guanylate cyclase and phosphoinositidase C. Mutant...
Topics
- Animals
- Chemotaxis
- Cyclic AMP
- Dictyostelium
- GTP-Binding Proteins
- Gene Expression Regulation, Enzymologic
- Mutation
- Phosphoric Diester Hydrolases
- Receptors, Cyclic AMP
- Second Messenger Systems