Article
Non-chemotactic Dictyostelium discoideum mutants with altered cGMP signal transduction.
The Journal of cell biology - 1 Dec 1993
Kuwayama H, Ishida S, Van Haastert P J
Abstract excerpt
Folic acid and cAMP are chemoattractants in Dictyostelium discoideum, which bind to different surface receptors. The signal is transduced from the receptors via different G proteins into a common pathway which includes guanylyl cyclase and acto-myosin. To investigate this common pathway, ten mutants which do not react chemotactically to both cAMP and folic acid were isolated with a simple new chemotactic assay....
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