Article
Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism.
FEBS letters - 29 Oct 1999
Oscarson M, McLellan R A, Gullstén H, Agúndez J A, Benítez J, Rautio A, Raunio H, Pelkonen O, Ingelman-Sundberg M
Abstract excerpt
The polymorphic human cytochrome P450 2A6 (CYP2A6) metabolises a number of drugs, activates a variety of precarcinogens and constitutes the major nicotine C-oxidase. A relationship between CYP2A6 genotype and smoking habits, as well as incidence of lung cancer, has been proposed. Two defective alleles have hitherto been identified, one of which is very common in Asian populations. Among Caucasians, an additional...
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