Article
PharmVar GeneFocus: CYP2A6.
Clinical pharmacology and therapeutics - 1 Oct 2024
Langlois Alec W R, Chenoweth Meghan J, Twesigomwe David, Scantamburlo Giada, Whirl-Carrillo Michelle, Sangkuhl Katrin, Klein Teri E, Nofziger Charity, Tyndale Rachel F, Gaedigk Andrea
Abstract excerpt
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the human CYP2A gene locus containing the highly polymorphic CYP2A6 gene. CYP2A6 plays a role in the metabolism of nicotine and various drugs. Thus, genetic variation can substantially contribute to the function of this enzyme and associated efficacy and safety. This GeneFocus provides an overview of the clinical significance of CYP2A6,...
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