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Article

Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.

Human mutation - 1 Oct 2002

Oscarson Mikael, McLellan Roman A, Asp Vendela, Ledesma MariCarmen, Bernal Ruiz Maria Luisa, Sinues Blanca, Rautio Arja, Ingelman-Sundberg Magnus

Abstract excerpt

The human CYP2A6 enzyme metabolizes certain drugs and pre-carcinogens and appears to be the most important enzyme for nicotine metabolism. At present, more than 10 different allelic variants are known that cause abolished or decreased enzyme activity. Genetic polymorphism in this gene might be of particular importance for an individual's need for nicotine and for susceptibility to lung and/or liver cancer. We...

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PMID: 12325023
DOI: 10.1002/humu.10126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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