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Article

Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development.

Oncogene - 25 Nov 2004

Eischen Christine M, Alt Jodi R, Wang Peng

Abstract excerpt

The tumor suppressor p19ARF inhibits Mdm2, which restricts the activity of p53. Complicated feedback and control mechanisms regulate ARF, Mdm2, and p53 interactions. Here we report that ARF haploinsufficiency completely rescued the p53-dependent effects of Mdm2 haploinsufficiency on B-cell development, survival, and transformation. In contrast to Mdm2+/- B cells, Mdm2+/- B cells deficient in ARF were similar to...

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Identifiers

PMID: 15467748
DOI: 10.1038/sj.onc.1208052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development.PMID 15467748Read ↗

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