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Article

p19 <sup>Arf</sup> induces p53-dependent apoptosis during Abelson virus-mediated pre-B cell transformation

27 Oct 1998

Abstract excerpt

The Ink4a/Arf locus encodes p16(Ink4a) and p19(Arf) and is among the most frequently mutated tumor suppressor loci in human cancer. In mice, many of these effects appear to be mediated by interactions between p19(Arf) and the p53 tumor-suppressor protein. Because Tp53 mutations are a common feature of the multistep pre-B cell transformation process mediated by Abelson murine leukemia virus (Ab-MLV), we examined...

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Identifiers

PMID: 9789064
DOI: 10.1073/pnas.95.22.13194

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p19 <sup>Arf</sup> induces p53-dependent apoptosis during Abelson virus-mediated pre-B cell transformationPMID 9789064Read ↗

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