Article
Tumor spectrum in ARF-deficient mice.
Cancer research - 1 May 1999
Kamijo T, Bodner S, van de Kamp E, Randle D H, Sherr C J
Abstract excerpt
The p19ARF product of the INK4a/ARF locus is induced in response to potentially oncogenic hyperproliferative signals and activates p53 by interfering with its negative regulator, Mdm2. Mice lacking ARF are highly prone to tumor development, and in this study, 80% of these animals spontaneously developed tumors and died within their first year of life. Mice that were heterozygous for ARF also developed tumors...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- Carcinoma
- Cell Lineage
- Cocarcinogenesis
- Disease Progression
- Female
- Fibrosarcoma
- Gene Deletion
- Genes, p53
- Genotype
- Loss of Heterozygosity