Article
Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers.
Proceedings of the National Academy of Sciences of the United States of America - 26 Oct 1999
Kuismanen S A, Holmberg M T, Salovaara R, Schweizer P, Aaltonen L A, de La Chapelle A, Nyström-Lahti M, Peltomäki P
Abstract excerpt
Aberrant DNA methylation is a common phenomenon in human cancer, but its patterns, causes, and consequences are poorly defined. Promoter methylation of the DNA mismatch repair gene MutL homologue (MLH1) has been implicated in the subset of colorectal cancers that shows microsatellite instability (MSI). The present analysis of four MspI/HpaII sites at the MLH1 promoter region in a series of 89 sporadic colorectal...
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