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Clinicopathological features and microsatellite instability (MSI) in colorectal cancers from African Americans

26 Apr 2005

Abstract excerpt

African Americans (AAs) have a 1.5 times higher risk of colorectal carcinoma (CRC) than Caucasians. Gene silencing through CpG island hypermethylation has been associated with the genesis or progression of microsatellite instability (MSI) largely due to 1 target for hypermethylation being the DNA mismatch repair gene hMLH1; there is anecdotal evidence of an increased incidence of MSI among AAs. P16 and hMLH1 can...

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PMID: 15856472
DOI: 10.1002/ijc.21062

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