Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct methylation pattern and microsatellite instability in sporadic gastric cancer

29 Oct 1999

Abstract excerpt

Aberrant 5' CpG island methylation is an alternative mechanism of gene inactivation during the development of cancer as demonstrated for several tumor-suppressor genes. Also, marked relationship of microsatellite instability (MSI) and DNA methylation has been reported in sporadic colorectal cancer, which is a result of epigenetic inactivation of hMLH1 in association of promoter hypermethylation. In the present...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Epigenetics and DNA Methylation
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10495421
DOI: 10.1002/(sici)1097-0215(19991029)83:3<309::aid-ijc4>3.0.co;2-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct methylation pattern and microsatellite instability in sporadic gastric cancerPMID 10495421Read ↗

The profile of hMLH1 methylation and microsatellite instability in colorectal and non-small cell lung cancer.Semantic proximity Read ↗

MSI-L gastric carcinomas share the hMLH1 methylation status of MSI-H carcinomas but not their clinicopathological profile.Semantic proximity Read ↗

Microsatellite instability in gastric cancer is closely associated with hMLH1 hypermethylation at the proximal region of the promoter.Semantic proximity Read ↗

Mutation and methylation of hMLH1 in gastric carcinomas with microsatellite instability.Semantic proximity Read ↗

Distinct clinicopathologic and genetic profiles in sporadic gastric cancer with different mutator phenotypes.Semantic proximity Read ↗

hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability.Semantic proximity Read ↗

Concurrent hypermethylation of gene promoters is associated with a MSI-H phenotype and diploidy in gastric carcinomas.Semantic proximity Read ↗

Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers.Semantic proximity Read ↗

Distal Colorectal Cancers with Microsatellite Instability (MSI) Display Distinct Gene Expression Profiles that Are Different from Proximal MSI CancersSemantic proximity Read ↗

A distinct DNA methylation profile associated with microsatellite and chromosomal stable sporadic colorectal cancers.Semantic proximity Read ↗

High frequency of microsatellite instability in intestinal-type gastric cancer in Korean patients.Semantic proximity Read ↗

Aberrant methylation within RUNX3 CpG island associated with the nuclear and mitochondrial microsatellite instability in sporadic gastric cancers. Results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.