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Article

Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 26 Oct 1999

Heyer J, Escalante-Alcalde D, Lia M, Boettinger E, Edelmann W, Stewart C L, Kucherlapati R

Abstract excerpt

SMAD2 is a member of the transforming growth factor beta and activin-signaling pathway. To examine the role of Smad2 in postgastrulation development, we independently generated mice with a null mutation in this gene. Smad2-deficient embryos die around day 7.5 of gestation because of failure of gastrulation and failure to establish an anterior-posterior (A-P) axis. Expression of the homeobox gene Hex (the earliest...

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Share to Embryonic and Fetal Development
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10535967
DOI: 10.1073/pnas.96.22.12595
PMCID: PMC23005

Genes

SMAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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