Article
Detection of cyclophosphamide-induced mutations at the Hprt but not the lacI locus in splenic lymphocytes of exposed mice.
Environmental and molecular mutagenesis - 1 Jan 1999
Walker V E, Andrews J L, Upton P B, Skopek T R, deBoer J G, Walker D M, Shi X, Sussman H E, Gorelick N J
Abstract excerpt
The relative sensitivities and specificities of the endogenous Hprt gene and the lacI transgene as mutational targets were evaluated in splenic lymphocytes from male standard B6C3F1 mice (only Hprt assayed) and from lacI transgenic B6C3F1 mice treated at 6-7 weeks- of-age with the indirect-acting agent, cyclophosphamide (CP). To define the effects of the time elapsed since CP treatment on Hprt mutant frequencies...
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