Article
Relationships between exposure, cell loss and proliferation, and manifestation of Hprt mutant T cells following treatment of preweanling, weanling, and adult male mice with N-ethyl-N-nitrosourea.
Mutation research - 17 Dec 1999
Walker V E, Jones I M, Crippen T L, Meng Q, Walker D M, Bauer M J, Reilly A A, Tates A D, Nakamura J, Upton P B, Skopek T R
Abstract excerpt
Experiments were performed to characterize the age-related patterns of appearance and frequency of hypoxanthine-guanine phosphoribosyl transferase (Hprt) mutant T lymphocytes in thymus and spleen following exposure of preweanling (12-day-old), weanling (22-day-old), and young adult (8-week-old) male B6C3F1 mice to ethylnitrosourea (ENU). Mice were given single i.p. injections of 0 or 40 mg ENU/kg and then groups...
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