Article
Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue rats.
Mutation research - 17 Jul 1998
Chen T, Aidoo A, Manjanatha M G, Mittelstaedt R A, Shelton S D, Lyn-Cook L E, Casciano D A, Heflich R H
Abstract excerpt
The utility of the lacI transgene of Big Blue rats as a reporter of in vivo mutation was evaluated by comparing the frequency and types of mutations induced by thiotepa in the transgene and the endogenous Hprt gene. Transgenic rats were given i.p. injections of 1.4 mg/kg of thiotepa three times per week over a period of 4 weeks (a total dose of 16.8 mg/kg); 1 week after the last injection, mutation assays were...
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