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Article

Restoration by glycerol of p53-dependent apoptosis in cells bearing the mutant p53 gene.

International journal of radiation biology - 1 Sept 1999

Ohnishi T, Matsumoto H, Wang X, Takahashi A, Tamamoto T, Ohnishi K

Abstract excerpt

PURPOSE: Effective heat-induced cell death in cultured cells bearing a mutant p53 (mp53) gene was sought by glycerol treatment which led to conformational change from mp53 to wild-type p53 (wtp53) in p53-null murine fibroblasts transfected with mp53. MATERIALS AND METHODS: Heat sensitivity was measured using a colony-forming assay. For heat-induced apoptosis, gel electrophoresis was applied to detect DNA...

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Identifiers

PMID: 10528916
DOI: 10.1080/095530099139557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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