Article
Glycerol restores p53-dependent radiosensitivity of human head and neck cancer cells bearing mutant p53.
British journal of cancer - 1 Dec 2000
Ohnishi K, Ota I, Takahashi A, Ohnishi T
Abstract excerpt
Mutation or inactivation of p53 is known to be present in approximately 50% of human cancers. We propose here a novel strategy for overcoming this problem in mutant p53-targeting cancer therapies. We examined the restoration of radiation-induced p53-dependent apoptosis by a chemical chaperone (glycerol) in human head and neck cancer cells (SAS cells, showing wild-type p53 phenotype). SAS cells transfected with...
Topics
- Apoptosis
- Cell Survival
- DNA Fragmentation
- Dose-Response Relationship, Radiation
- Glycerol
- Head and Neck Neoplasms
- Humans
- Mutation
- Oligonucleotides
- Protein Binding
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53