Article
Glycerol enhances radiosensitivity in a human oral squamous cell carcinoma cell line (Ca9-22) bearing a mutant p53 gene via Bax-mediated induction of apoptosis.
Oral oncology - 1 Jul 2005
Imai Yuichiro, Ohnishi Ken, Yasumoto Jun-ichi, Kajiwara Atsuhisa, Yamakawa Nobuhiro, Takahashi Akihisa, Ohnishi Takeo, Kirita Tadaaki
Abstract excerpt
Radiotherapy for oral squamous cell carcinomas is limited in its efficacy and in its ability to improve the survival rate in patients at an advanced stage. A protocol is described here which may elevate the therapeutic efficacy of radiation for these cells. The addition of glycerol to the culture medium prior to irradiation of an oral squamous cell carcinoma cell line (Ca9-22) bearing a mutant p53 (mp53) gene was...
Topics
- Apoptosis
- Blotting, Western
- Carcinoma, Squamous Cell
- Cell Survival
- Culture Media
- DNA Fragmentation
- Genes, p53
- Glycerol
- Humans
- Mouth Neoplasms
- Mutation
- Proto-Oncogene Proteins c-bcl-2
- Radiation Tolerance