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Article

Heat-induced apoptosis via caspase-3 activation in tumour cells carrying mutant p53.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group - 1 Jan 2000

Kobayashi D, Watanabe N, Yamauchi N, Okamoto T, Tsuji N, Sasaki H, Sato T, Niitsu Y

Abstract excerpt

Apoptosis plays an important role in heat-induced cell death. However, the mechanism of heat-induced apoptosis has not yet been elucidated. In the present study, the signal transduction pathway underlying heat-induced apoptosis was investigated in heat-resistant HeLa cells carrying mutant p53 gene and heat sensitive HeLa cells that had been transduced with an antisense TNF gene. Induction of mutant p53, but not...

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PMID: 11129259
DOI: 10.1080/02656730050199322

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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