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Article

Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53.

BMC biotechnology - 19 Apr 2002

Ohnishi Takeo, Ohnishi Ken, Takahashi Akihisa

Abstract excerpt

BACKGROUND: We have previously reported that glycerol acts as a chemical chaperone to restore the expression of WAF1 in some human cancer cell lines bearing mutant p53. Since the expression of WAF1 is up-regulated by activated wildtype p53, glycerol appears to restore wtp53 function. The aim of the present study is to examine the restoration of heat-induced p53-dependent apoptosis by glycerol in human...

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Identifiers

PMID: 11965244
DOI: 10.1186/1472-6750-2-6
PMCID: PMC111188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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