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Article

BRCA1: mechanisms of inactivation and implications for management of patients.

Lancet (London, England) - 28 Sept 2002

Kennedy Richard D, Quinn Jennifer E, Johnston Patrick G, Harkin D Paul

Abstract excerpt

The BRCA1 gene was cloned in 1994 as one of the genes that conferred genetic predisposition to early-onset breast and ovarian cancer. Since then, a genetic test for identification of high-risk individuals has been developed. Despite being implicated in many important cellular pathways, including DNA repair and regulation of transcription, the exact mechanism by which inactivation of BRCA1 might lead to malignant...

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Source

Identifiers

PMID: 12383682
DOI: 10.1016/S0140-6736(02)11087-7

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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