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Article

Lost-a-fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation.

Development (Cambridge, England) - 1 Mar 2001

Mintzer K A, Lee M A, Runke G, Trout J, Whitman M, Mullins M C

Abstract excerpt

TGFbeta signaling pathways of the bone morphogenetic protein (BMP) subclass are essential for dorsoventral pattern formation of both vertebrate and invertebrate embryos. Here we determine by chromosomal mapping, linkage analysis, cDNA sequencing and mRNA rescue that the dorsalized zebrafish mutant lost-a-fin (laf) is defective in the gene activin receptor-like kinase 8 (alk8), which encodes a novel type I TGFbeta...

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PMID: 11222141
DOI: 10.1242/dev.128.6.859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lost-a-fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation.PMID 11222141Read ↗

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The novel type I serine-threonine kinase receptor Alk8 binds TGF-beta in the presence of TGF-betaRII.Semantic proximity Read ↗

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The roles of BMPs, BMP antagonists, and the BMP signaling transducers Smad1 and Smad5 during dorsoventral patterning of the zebrafish embryo.Semantic proximity Read ↗

Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis.Semantic proximity Read ↗

The role of maternal Activin-like signals in zebrafish embryos.Semantic proximity Read ↗

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