Article
Subunit-specific NMDA receptor trafficking to synapses.
Neuron - 18 Jul 2002
Barria Andres, Malinow Roberto
Abstract excerpt
To elucidate mechanisms controlling the number and subunit composition of synaptic NMDA-Rs in hippocampal slice neurons, the NR1, NR2A, and NR2B subunits were optically and electrophysiologically tagged. The NR2 subunit directs delivery of receptors to synapses with different rules controlling NR2A and NR2B. Synaptic incorporation of NR2B-containing receptors is not limited by synaptic transmission nor enhanced...
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