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Article

Constitutive activation of the N-methyl-D-aspartate receptor via cleft-spanning disulfide bonds.

The Journal of biological chemistry - 1 Aug 2008

Blanke Marie L, VanDongen Antonius M J

Abstract excerpt

Although the N-methyl-D-aspartate (NMDA) receptor plays a critical role in the central nervous system, many questions remain regarding the relationship between its structure and functional properties. In particular, the involvement of ligand-binding domain closure in determining agonist efficacy, which has been reported in other glutamate receptor subtypes, remains unresolved. To address this question, we...

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Identifiers

PMID: 18450751
DOI: 10.1074/jbc.M709190200
PMCID: PMC2490796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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