Constitutive activation of the N-methyl-D-aspartate receptor via cleft-spanning disulfide bonds.

Abstract excerpt

Although the N-methyl-D-aspartate (NMDA) receptor plays a critical role in the central nervous system, many questions remain regarding the relationship between its structure and functional properties. In particular, the involvement of ligand-binding domain closure in determining agonist efficacy, which has been reported in other glutamate receptor subtypes, remains unresolved. To address this question, we...

Topics

• Animals
• Cysteine
• Disulfides
• Electrophysiology
• Glycine
• Molecular Conformation
• Mutagenesis, Site-Directed
• Mutation
• Oocytes
• Point Mutation
• Protein Structure, Tertiary