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Article

Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptors.

Neuropharmacology - 1 Jul 2007

von Engelhardt Jakob, Coserea Irinel, Pawlak Verena, Fuchs Elke C, Köhr Georg, Seeburg Peter H, Monyer Hannah

Abstract excerpt

Excitotoxicity, exacerbating acute brain damage from brain trauma or stroke, is mediated in part by excessive Ca(2+)-influx from prolonged NMDA receptor activation. However, the contribution to excitotoxicity by each of the main NMDAR subtypes in glutamatergic forebrain neurons, the NR2A- and NR2B-types, has remained enigmatic. Here, we investigated this issue by use of pharmacological and genetic tools in...

Topics

Analysis of Variance
Animals
Calcium Channel Blockers
Cell Death
Cells, Cultured
Cerebral Cortex
Dose-Response Relationship, Drug
Drug Interactions
Embryo, Mammalian
Excitatory Amino Acid Agonists

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Excitatory Amino Acid Antagonists

Mice

Mice, Knockout

Mutation

N-Methylaspartate

Neurons

Patch-Clamp Techniques

Piperidines

Source

Identifiers

PMID: 17570444
DOI: 10.1016/j.neuropharm.2007.04.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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