Article
Differential regulation of the human insulin gene transcription by GG1 and GG2 elements with GG- and C1-binding factors.
Biochimica et biophysica acta - 3 Sept 1999
Tomonari A, Yoshimoto K, Mizusawa N, Iwahana H, Itakura M
Abstract excerpt
Using a human growth hormone reporter system, the introduced mutations in GG1 alone or both GG elements of GG1 and GG2 in the human insulin promoter abolished 94 or 96% of the beta-cell-specific transcriptional activity in a pancreatic islet beta-cell line of MIN6, while the mutations in GG2 or its total deletion abolished 85 or 86% of the transcriptional activity. When linked to the thymidine kinase promoter,...
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