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Article

The role of the proximal CTAAT-box of the rat glucokinase upstream promoter in transcriptional control in insulin-producing cells.

Biological chemistry Hoppe-Seyler - 1 Feb 1994

Leibiger B, Walther R, Leibiger I B

Abstract excerpt

Sequence analysis of the 5'flanking region of the beta-cell specific transcription unit of the rat glucokinase gene (r beta GK) revealed the presence of sequence motifs very similar to the IEB-(Far)-box and a CT-motif which play a crucial role in transcriptional control of insulin genes. 5'deletional analysis of the r beta GK proximal promoter element (localized between nucleotides -278 and -49) as well as site...

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Identifiers

PMID: 8192863
DOI: 10.1515/bchm3.1994.375.2.93

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