Article
The role of the proximal CTAAT-box of the rat glucokinase upstream promoter in transcriptional control in insulin-producing cells.
Biological chemistry Hoppe-Seyler - 1 Feb 1994
Leibiger B, Walther R, Leibiger I B
Abstract excerpt
Sequence analysis of the 5'flanking region of the beta-cell specific transcription unit of the rat glucokinase gene (r beta GK) revealed the presence of sequence motifs very similar to the IEB-(Far)-box and a CT-motif which play a crucial role in transcriptional control of insulin genes. 5'deleti...
Topics
- Amyloid
- Animals
- Base Sequence
- Cell Line
- Cricetinae
- DNA Mutational Analysis
- Enhancer Elements, Genetic
- Gene Expression Regulation, Enzymologic
- Glucokinase
- Humans
- Insulin
- Islet Amyloid Polypeptide
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Nuclear Proteins
- Oligonucleotide Probes
- Plasmids