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Article

Involvement of PDX-1 in activation of human insulin gene transcription

1 Feb 2006

Abstract excerpt

Islet beta cell-specific transcription of the insulin gene is mediated through the binding of the islet-enriched PDX-1, BETA2, and MafA transcription factors to conserved 5'-flanking region regulatory elements. However, additional non-conserved sequences within this region are also significant in regulating expression. Thus, PDX-1 binds to and activates the GG2 element located between nucleotides -145 and -140 of...

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Identifiers

PMID: 16461554
DOI: 10.1677/joe.1.06510

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